• CRF and urocortin I are

  2019-10-12

  

  CRF and urocortin I are not only readily found throughout the spinal cord (Korosi et al., 2007), CRF analogs are clearly able to alter nociceptive signals (Imbe et al., 2010; Lariviere and Melzack, 2000). However, it was unclear whether they are released endogenously and involved in the spinal modul

• The mechanisms in the central

  2019-10-12

  

  The mechanisms in the central nervous system (CNS) controlling the sympathetic tone of the nor-NOHA acetate are associated to behavioral strategies, such as those involved in response to stress. In this regard, morphine withdrawal induces profound and severe stress reactions evidenced by enhancemen

• br Progestogens and venous thromboembolism

  2019-10-12

  

  Progestogens and venous thromboembolism: clinical data Progestogens and haemostatis: biological studies For many years, the effect of HT on haemostatis has been largely investigated in observational studies as well as in high evidence level studies among users of oral and transdermal estrogens

• RNA seq results also support the

  2019-10-12

  

  RNA-seq results also support the similarity between ESC- and YS-derived B-1 progenitors. Bmi1 expression, known as an important gene for self-renewal ability in stem cells, was reduced in ESC-derived B cells compared with YS-derived B cells, and Bmi1 overexpression improved the engraftment of ESC-de

• In particular EphB has been one of

  2019-10-12

  

  In particular, EphB4 has been one of the most studied receptor of the Eph family: inhibition of EphB4 expression using interfering-RNA or antisense oligonucleotides inhibited proliferation, survival and invasion of PC3 prostate cancer apigenin in vitro and in vivo. Inhibition of EphB4 signalling us

• Nitric oxide synthase NOS is a predominant enzyme

  2019-10-12

  

  Nitric oxide synthase (NOS) is a predominant enzyme of immune system, which elaborates nitric oxide (NO) from the amino Vinorelbine arginine (Arg). NO mediates vasodilatation, blood pressure regulation, neurotransmission, host defense, and macrophage-mediated immunity, among an array of other functi

• br Halogenases Enzymatic C H activation leading to

  2019-10-12

  

  Halogenases Enzymatic C–H activation leading to halogenation is another emerging area in biocatalysis [55,56]. Incorporation of halogen atoms during medicinal chemistry eff ;orts is a well-established practice, presenting an effective means to control the molecule’s bioactivity and physicochemical

• First of all it should be emphasized that

  2019-10-12

  

  First of all, it should be emphasized that, although cPLA2α manifests a marked selectivity for phospholipids that contain AA at the sn-2 position, this does not mean in any way that, in cells, the enzyme cannot hydrolyze other fatty acyl residues to a significant extent even if this occurs at a lowe

• br Results br Discussion PKR

  2019-10-12

  

  Results Discussion PKR is activated by viral dsRNA and exerts its antiviral effect through phosphorylation of eIF2a. Because eIF2a phosphorylation leads to attenuation of protein synthesis, many viruses have evolved mechanisms to block or suppress PKR activation. Some viruses use alternative t

• Nimodipine administration also inhibited the eIF ATF singnal

  2019-10-12

  

  Nimodipine administration also inhibited the eIF2α/ATF4 singnaling which is a crucial evolutionarily conserved adaptive pathway during cellular stresses including hypoxia and ischemia (Evans et al., 2016; Manwani and McCullough, 2013). While, the eIF2a/ATF4 pathway, activated by different forms of s

• br Results br Discussion PKR

  2019-10-12

  

  Results Discussion PKR is activated by viral dsRNA and exerts its antiviral effect through phosphorylation of eIF2a. Because eIF2a phosphorylation leads to attenuation of protein synthesis, many viruses have evolved mechanisms to block or suppress PKR activation. Some viruses use alternative t

• In contrast to SQLE HMGCR could be

  2019-10-12

  

  In contrast to SQLE, HMGCR could be efficiently degraded in SB-3CT lacking UBE2J2. However, this was not the case in cells devoid of UBE2G2, as these cells were unable to support 25-hydroxycholesterol (25-HC)-stimulated degradation of HMGCR (Fig. 1C). This finding is consistent with our recently rep

• br Introduction The identification of

  2019-10-12

  

  Introduction The identification of genetic variants that influence susceptibility to Parkinson\'s disease (PD) determines functional studies, the generation of model systems and directs therapeutic strategies. To date, classical candidate gene association studies and genome-wide approaches have f

• Here we explored the relative contribution of

  2019-10-12

  

  Here we explored the relative contribution of D1-like and D2-like receptor subtypes in the control of glutamate release, as well as their pharmacological properties and their interactions modulating the release. The pharmacological parameters (EC50 and Emax) of dopamine for the different types of re

• Tamoxifen is included in the treatment protocol

  2019-10-12

  

  Tamoxifen is included in the treatment protocol of ER+ breast carcinoma patients routinely. Although tamoxifen improves patients\' survival, unfortunately a large number of ER+ patients don\'t response to tamoxifen treatment (Yager and Davidson, 2006). Detection of molecular markers which could take

14081 records 922/939 page Previous Next First page 上5页 921922923924925 下5页 Last page