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br Materials and methods br Results
2020-08-27
Materials and methods Results and discussion Concluding remarks Enzymatic production of bioactive 9-cis-11-trans-conjugated linoleic sirolimus solubility is part of a detoxification mechanism against linoleic acid which is a toxic and stress factor for many lactic bacteria such as Lactobac
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In summary our findings show that LPS can activate
2020-08-26
In summary, our findings show that LPS can activate CysLT2R on microglial Methscopolamine synthesis to induce microglial inflammation and microglia-dependent neuronal death. Furthermore, pharmacological inhibition or knocking down of CysLT2R expression protects neurons against neurotoxicity via sup
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Finally unilateral microinjection of CP
2020-08-26
Finally, unilateral microinjection of CP-376395, Astressin 2B, CP-376395 + CRF or ASTR 2B + CRF into the BLA (Fig. 3A) or CeA (Fig. 3B) did not significantly alter spontaneous motor activity in the open field test (F4,24 = 0.148, P > 0.05; F4,29 = 0.290, P > 0.05 in the BLA and CeA, respectively, AN
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Endothelins ETs are peptides expressed in both the
2020-08-26
Endothelins (ETs) are peptides expressed in both the peripheral and the central nervous systems, which can contribute to sensory changes seen in animal models of inflammatory, cancer and neuropathic pain [10], [11]. All three mammalian isoforms (ET-1, ET-2 and ET-3) activate specific G protein-coupl
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The new ESC guidelines incorporate data
2020-08-26
The new ESC guidelines incorporate data from a network meta-analysis of 100 studies confirming that new-generation drug-eluting stents (DES) improve survival compared with medical treatment, although this has not been demonstrated in any individual study. REVASCULARIZATION IN NON–ST-ELEVATION ACU
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There are conflicting studies on ET
2020-08-26
There are conflicting studies on ET axis and its relationship with clinicopathologic parameters in various cancers. Endothelin axis expression in the tissue and in blood has been associated with advanced cancer characteristics in colorectal, breast, and prostate cancer, while showing no linkage to c
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ER stress was monitored by both an increase of the
2020-08-26
ER stress was monitored by both an increase of the ER chaperone (GRP78, GRP94) and the activation of the ER resident caspase-12. ER stress response (also known as the unfolded protein response) is a defense mechanism against various cellular stresses which causes accumulation of unfolded proteins in
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Similar to EGFR another receptor tyrosine
2020-08-26
Similar to EGFR, another receptor tyrosine kinase (RTK), fibroblast growth factor receptor 4 (FGFR4), is gaining attention in the lung cancer setting. The protein expression of this receptor has been recently associated with a negative impact on lung cancer prognosis, supporting the idea that FGFR4
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Acknowledgment This work was supported by
2020-08-26
Acknowledgment This work was supported by the Swedish Research Council, the Knut and Alice Wallenberg Foundation, the Göran Gustafsson Foundation, the Swedish Pain Relief Foundation, the Torsten Söderbergs Stiftelse, the Swedish Children\'s Cancer Foundation, and the Swedish Cancer Society. The
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In summary A is a potent orally
2020-08-24
In summary, A-216546 is a potent, orally available endothelin receptor antagonist with a high selectivity for the endothelin ETA receptor. The potency and bioavailability of A-216546 suggest that it will have important utility for preclinical evaluation of the pathophysiology of the endothelin syste
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Introduction Penetrator with Enhanced Lateral Effect PELE is
2020-08-24
Introduction Penetrator with Enhanced Lateral Effect (PELE) is a kind of ammunition which consists of a low-density material as the filling and a high-density material as the jacket [1,2]. When PELE impact target, the jacket is radially accelerated, expanded and fractured because of distinctive lat
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Early VL diagnosis makes it possible to formulate a quicker
2020-08-24
Early VL diagnosis makes it possible to formulate a quicker and more effective treatment against the disease, which could increase the possibility of a cure for the patients, as well as reduce the toxicity of the drugs (Coelho et al., 2009); however, conventional and molecular parasitological method
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Among the Ub interactions observed
2020-08-24
Among the ~Ub interactions observed in the HOIP structure is one that involves a RING2 domain (from the non-cognate HOIP) [47]. A similar binding interaction was defined between HHARI RING2 and the hydrophobic patch on Ub by NMR [54]. HHARI RING2 mutations that ablate the interaction inhibit formati
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Haj Yahya et al applied
2020-08-24
Haj-Yahya et al. [52] applied native chemical ligation for the construction of diubiquitin probes. They attached a cysteine residue to the lysine side chain of the proximal ubiquitin and ligated the distal module using the C-terminal thioester of ubiquitin. Elimination of the sulfur thiostrepton mg
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br Conclusion The role of DNA PK target
2020-08-24
Conclusion The role of DNA-PK target in DNA DSB repair renders this guggulsterone receptor kinase of great medicinal interest in cancer chemotherapy especially the cancer types of linked to DNA defects. Due to the absence of 3D DNA-PK target structure, different ligand-based methods were applied
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