• A further generally applicable approach for the synthesis of

  2022-02-25

  

  A further generally applicable approach for the synthesis of N-linked glycopeptides involves the convergent Lansbury aspartylation of glycosylamines. Here, the detrimental formation of aspartimides during the activation of the side chain aspartate can be prevented through the use of Ser/Thr pseudopr

• br Methods and materials br Results and

  2022-02-25

  

  Methods and materials Results and discussion Conclusions This is the first study that attempted to isolate, purify and identify the characteristics of Rufinamide mg from ginseng. In vitro studies have demonstrated that PGL-1 efficiently suppressed SH-SY5Y cell apoptosis induced by Aβ25–35,

• We recently reported the first

  2022-02-25

  

  We recently reported the first cyclopropene-analog of the amino Nemadectin neurotransmitter glutamate (Fig. 2A) [27]. This first-generation cyclopropene-glutamate expanded the only other documented report of a cyclopropene-neurotransmitter (cyclopropene-GABA analog by Reissig and coworkers) [28]. We

• br Conflict of interest br Introduction

  2022-02-25

  

  Conflict of interest Introduction Milk and dairy products are nutritious foods that provide lactose, calcium, phosphorous, magnesium and proteins, among other nutrients, which have been reported to have a fundamental role in bone development and healthy diets. An adequate consumption of dairy

• Studies on FXR knockout mice demonstrated that FXR

  2022-02-24

  

  Studies on FXR knockout mice demonstrated that FXR activity is necessary to maintain a proper integrity of intestinal tight junction [18]. HF diet-induced bowel dysfunction impaired FXR activity and affected fecal BA profile. Generally, it augmented the concentration of secondary BAs in the colon e.

• Introduction Risk factors for colorectal cancer CRC include

  2022-02-24

  

  Introduction Risk factors for colorectal cancer (CRC) include high-fat diets, sedentary lifestyles, obesity, diabetes, and elevated serum levels of toxic bile acids (BAs) (de Aguiar Vallim et al., 2013, Degirolamo et al., 2011, Downes and Liddle, 2008, Font-Burgada et al., 2016, Kuipers et al., 20

• br Results br Discussion Immune mediated chronic inflammator

  2022-02-24

  

  Results Discussion Immune-mediated chronic inflammatory diseases (e.g. rheumatoid arthritis, psoriasis, multiple sclerosis, and inflammatory bowel disease) are characterized by a dysregulated migration of leukocytes from blood vessels into inflamed tissues. To date, several new targets and inh

• In spite of decades of research the mechanisms of

  2022-02-24

  

  In spite of decades of research the mechanisms of SV endocytosis and recycling remain controversial. Accumulating evidence suggests that SV endocytosis occurs by more than one mechanism (e.g. clathrin-independent endocytosis, clathrin-mediated endocytosis, bulk endocytosis; reviewed in (Dittman and

• SCH is a H R receptor antagonist introduced

  2022-02-24

  

  SCH-497079 is a H3R receptor antagonist introduced by Schering-Plough, without any publicized pharmacological and structural information. A Phase II clinical trial assessment of SCH-497079 on weight has been completed in a multicenter, randomized, parallel-group and placebo-controlled study in obese

• In recent years the Hippo signaling

  2022-02-24

  

  In recent years, the Hippo signaling pathway has emerged as an important regulator balancing cell proliferation and differentiation [[5], [6], [7]]. The pathway components, first described in the fruit fly Drosophila melanogaster, are highly conserved across different phyla [6]. The signaling pathwa

• br Obesity tips to a systematic failure in

  2022-02-24

  

  Obesity tips to a systematic failure in the overall metabolic regulation; it is a major global health problem and is linked to several metabolic diseases such as (T2D) (see ), (NAFLD), and cardiovascular disorders. The prevalence of such metabolic disorders has increased dramatically worldwide , ,

• The RAS RAF MEK ERK pathway is a central controller

  2022-02-24

  

  The RAS/RAF/MEK/ERK pathway is a central controller of cell proliferation and survival and, consequently, alterations to some of its components lead to hyperactivation of the pathway, an event related to numerous types of cancer [172]. High rates of alterations to this pathway are found in leukemia,

• br Introduction Human immunodeficiency virus HIV is

  2022-02-24

  

  Introduction Human immunodeficiency virus-1 (HIV-1) is a retrovirus that primarily infects components of the human immune system, such as CD4+ T cells, macrophages and dendritic FPH1 (Clapham and McKnight, 2001). HIV directly and indirectly destroys CD4+ T cells, which leads to severe immunodefi

• While NR upregulation in the spinal cord is known

  2022-02-23

  

  While NR1 upregulation in the spinal cord is known to contribute to pathological pain [7], [22] and furthermore, NR1 expression in the spinal cord has been shown to be reduced by continuous administration of the GlyT1-inhibitor ALX5407 [23], little is known about possible expressional changes of NR1

• Functional studies based on patch clamp electrophysiology pr

  2022-02-23

  

  Functional studies based on patch-clamp electrophysiology provide additional information on the active state of GlyR α1. Current-voltage measurements from single regorafenib side effects in outside-out patches at symmetric 145-mM chloride concentration yielded a unitary conductance of 86 pS for the

14081 records 461/939 page Previous Next First page 上5页 461462463464465 下5页 Last page