• Magtanong et al observed that caspase dependent apoptotic

  2022-07-18

  

  Magtanong et al. (2019) observed that caspase-dependent apoptotic lipotoxicity of saturated fatty acids is suppressed by exogenous MUFAs. This may explain the ability of MUFAs to prevent atherosclerosis, in contrast to the pathogenicity of saturated fatty acids. Moreover, MUFAs may promote while PUF

• The results of our analysis of Fas alleles Fas A

  2022-07-18

  

  The results of our analysis of Fas alleles, Fas 670 A>G, FasL alleles, and FasL IVS2nt 124 A>G for cases and controls are shown in Table 2. For Fas 670, we found statistically significant differences between the two groups regarding the AA secretin receptor (P=0.040) and GG/AG (P=0.040) as well as

• br Introduction It is well known that conventional cancer

  2022-07-18

  

  Introduction It is well known that conventional cancer treatment strategies, such as surgery, radiotherapy, and chemotherapy all have their own limitations, which lead to an unsatisfactory therapeutic effect. Under this situation, the combination of two or more therapeutic strategies has recently

• br Results and Discussion The Set sequence is homologous

  2022-07-18

  

  Results and Discussion The Set7 sequence is homologous to the other identified histone methyltransferases in S. pombe (Figure S1) and also shares similarity with human HMTases, H3K9 GLP/Ga9, and H4K20 SUV420H1 (Figure S1). Set7 fused with the GFP (Set7-GFP) localized in the nucleus and cytoplasm

• In the CNS histamine is known to

  2022-07-18

  

  In the CNS, Memantine hydrochloride is known to regulate sleep and wakefulness, learning and memory, feeding, and energy. Here, we address its actions in relation to CNS disorders, and emphasize potential clinical applications of histamine receptor ligands (Table 1). In addition, as the effect of h

• It is important to note that histamine H

  2022-07-18

  

  It is important to note that histamine H1 and H2 receptors are coupled to different G proteins and that their crossinterference induced by histamine H1 and H2 receptor inverse agonists depends on the cointernalization mechanism. To date, histamine H1 and H2 receptor inverse agonist have shown to int

• Methimazole In the Hedgehog signaling pathway cholesterol is

  2022-07-18

  

  In the Hedgehog signaling pathway, cholesterol is required to activate SMO (Cooper et al., 2003), the downstream target of PTCH1. A previous study (Bidet et al., 2011) reported that Patched expression in yeast Methimazole increased extrusion of a fluorescent boron dipyromethanene sterol derivative

• The majority of HCV unaware individuals for which HCV

  2022-07-18

  

  The majority of HCV-unaware individuals, for which HCV RNA was obtainable, had active HCV infection and overall almost one-fifth of them had advanced liver disease according to the FIB-4 score; these persons can be classified as having a late HCV diagnosis and are in immediate need of HCV treatment

• Introduction Soluble guanylyl cyclase sGC is a key protein

  2022-07-18

  

  Introduction Soluble guanylyl cyclase (sGC) is a key protein in the regulation of multiple physiological functions in mammalian physiology [1,2]. Upon stimulation by nitric oxide (NO) [3], sGC generates cyclic guanosine monophosphate (cGMP) from guanosine-5′ triphosphate and activates protein kinas

• hop over to here Similar to GPR A activation of G protein co

  2022-07-16

  

  Similar to GPR109A, activation of G-protein-coupled receptor 81 (GPR81, also called HCAR1 (hydroxycarboxylic hop over to here receptor 1)) by lactate suppresses lipolysis (Fig. 1), suggesting GPR81 to be a potential drug target for treating T2DM (Boyd et al., 1974, Cai et al., 2008, Gold et al., 196

• br TGR agonists current developments and future landscape

  2022-07-16

  

  TGR5 agonists: current developments and future landscape The amphipathic nature of bile acids is crucial in aiding the digestion and ABH of vitamins and fats. With the emerging roles of bile acids in the regulation of energy and glucose homeostasis through TGR5, the pharmaceutical industry has f

• It is essential to maintain genome

  2022-07-16

  

  It is essential to maintain genome integrity and stability which is assaulted by oxidative stress. To perform this function, all human cells have well developed repair systems. Base excision repair (BER) system is the most effective pathway responsible to revert back lesions caused by oxidative stre

• br Introduction Edible bird s nest EBN known as

  2022-07-16

  

  Introduction Edible bird's nest (EBN), known as the health and precious food, is produced from the saliva secretion of several different swiftlet species. Researches have shown the nutritional value of the EBN with the containing of glycoproteins, carbohydrates, essential amino acids, minerals an

• Nano SiO was a kind of versatile material for enzyme

  2022-07-16

  

  Nano-SiO2 was a kind of versatile material for enzyme immobilization because of its excellent properties, including low cost, lack of toxicity, high stability, large specific surface area and high biocompatibility [10]. After the immobilization on nano-SiO2, the selectivity of enzymatic reactions wo

• br Concluding remarks br Introduction

  2022-07-16

  

  Concluding remarks Introduction The hair LY 2389575 hydrochloride receptor of vestibular organs detect linear and rotational head movements, providing sensory information that is essential for normal postural and visual reflexes. Most vestibular hair cells are produced during embryonic develo

14081 records 382/939 page Previous Next First page 上5页 381382383384385 下5页 Last page