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Camptothecin is a type of topo I
2022-09-02
Camptothecin is a type of topo I inhibitor, and its prodrugs irinotecan and topotecan have been approved by the FDA for clinical cancer treatment. It has been reported that SAHA can enhance the cytotoxicity of camptothecin derivatives in several cancer cell lines20., 21., 22., 23., 24.. Taking the s
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Roughly million people who are currently infected with
2022-09-02
Roughly 15 million people who are currently infected with HBV are co-infected with the hepatitis D virus (HDV) (WHO, 2017b). The superinfection not only leads to more severe liver damage and early onset of cirrhosis, but also to a higher mortality than HBV mono-infection (Rizzetto, 1983; WHO, 2017b)
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In recent large clinical studies AIM HIGH and HPS
2022-09-01
In recent large clinical studies, AIM-HIGH and HPS2-THRIVE, the additional treatment of nicotinic Baicalin australia to statin-based LDL-C lowering therapy did not decrease the major vascular events on the patients who had atherosclerotic vascular diseases [43,44]. In the AIM-HIGH study, the second
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One difficulty in studying gp is that it
2022-09-01
One difficulty in studying gp120 is that it binds to more than one receptor. Understanding how Norfloxacin respond to gp120 is complex because of this promiscuity. In an attempt to establish the contribution of CXCR4 in the antagonistic effect of gp120 on morphine-induced antinociception, AMD3100 w
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br Introduction The generic antifibrinolytic drug tranexamic
2022-09-01
Introduction The generic antifibrinolytic drug tranexamic Epidermal Growth Factor (EGF), human recombinant synthesis (TXA) inhibits the protein-protein interaction between plasminogen and fibrin [9]. TXA is frequently used to reduce bleeding in various hemorrhagic conditions, such as during surg
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br Conclusion Membrane transporters remain relatively
2022-09-01
Conclusion Membrane transporters remain relatively understudied in human disease, especially TBI (Cesar-Razquin et al., 2015), and considerably less is known in terms of expression, function and substrates of membrane transporters in pediatric patients. However, their importance in maintaining ar
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To maintain low Glu concentrations in the
2022-09-01
To maintain low Glu concentrations in the synaptic cleft below the affinity of its receptors, this amino description is rapidly removed from the extracellular space by a family of sodium-dependent high-affinity transport systems located mainly in the plasma membrane of perisynaptic astrocytes, and
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Ropivacaine HCl br Materials and methods br Results br Discu
2022-09-01
Materials and methods Results Discussion In nerve terminals, Na+-dependent glutamate transporters of the plasma membrane are responsible for the maintenance of low (non-toxic) extracellular glutamate concentrations and accomplish uptake of glutamate into the Ropivacaine HCl of neurons and
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br Regulation of Glu transporters The pivotal role of
2022-09-01
Regulation of Glu transporters The pivotal role of Glu transporters in the fine tuning and turnover of this excitatory amino terbinafine hydrochloride calls for a detailed characterization of its regulation. Several general mechanisms that modify Glu uptake activity have been described. These inc
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After ischemia expression of transcription factors including
2022-09-01
After ischemia, expression of transcription factors, including products of immediate early genes, stress proteins and neurotrophic factors are also altered in CA1 neurons78, 79. These proteins are potential candidates for downregulating of GluR2 expression by reducing mRNA transcription or stability
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Despite the potential promise of both of these peptides such
2022-09-01
Despite the potential promise of both of these peptides, such compounds are still susceptible to efficient renal filtration (Emmanouel et al., 1978, Holst, 1991, Deacon et al., 1996). However, numerous studies have demonstrated that fatty LB Broth, Miller sale dervatisation of related regulatory pe
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Some other neuroinflammatory neuroendocrine and neurotrophic
2022-09-01
Some other neuroinflammatory, neuroendocrine, and neurotrophic pathway but not the ghrelin/GHSR pathway may mediate the CUMS-induced depression- and anxiety-like behaivors. The endogeous ghrelin/GHSR pathway activated by chronic mild stress may plays a role in homeostasis. With respect to the mechan
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purinergic receptor Though regulation of ghrelin interaction
2022-09-01
Though regulation of ghrelin interaction with GHSR has not been described previously, a precedent for a similar regulatory mechanism exists in the form of the interaction between Agouti-Related Protein (AgRP) and melanocortin receptor subtypes MC3R and MC4R (Ollmann, 1997). AgRP is produced by hypot
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In the last years a plethora of studies overstepped the
2022-09-01
In the last years, a plethora of studies overstepped the classic concept of the ENS as purely modulator of GI secretion and motility, focusing on its potential as source of substances acting on immune cells and consequently involved in the control of local inflammatory events, as in the Inflammatory
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Earlier we have showed that
2022-09-01
Earlier we have showed that tumor associated sFas mRNA isoform profile and splicing factors expression levels in solid tumors do not correspond to profiles that are observed in cell lines [45]. In the present study, for the first time we show that Fas but not Rac1 pre-mRNA's alternative splicing is
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