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GPR is a G protein coupled receptor that has
2022-09-09
GPR55 is a G protein-coupled receptor that has pro-oncogenic properties and whose expression correlates with tumor aggressiveness and increased activation of extracellular signal-regulated kinase (ERK) cascade [12]. Elevated expression of GPR55 has been linked to aggressiveness in human pancreatic,
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GPR A a G protein coupled receptor located
2022-09-09
GPR109A, a G-protein-coupled receptor located mainly on adipocyte cell membranes, has been identified as the molecular target for nicotinic Paxilline [[5], [6], [7]] and mediator of NEFA reduction [5]. As a mechanism of NEFA-lowering, it is recognized that activation of GPR109A leads to Gi-mediated
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TXA has been shown to be a competitive antagonist
2022-09-09
TXA has been shown to be a competitive antagonist on the GABAA receptor and potentially also the glycine [7], [12], [15] receptor. Furtmuller et al. showed that TXA right-shifted the GABA CRC by one order of magnitude [7], while in our study TXA similarly right-shifted the GABA EC50 value from 0.33
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br Acknowledgements We thank LetPub www letpub com for its
2022-09-09
Acknowledgements We thank LetPub (www.letpub.com) for its linguistic assistance during the preparation of this manuscript. This work was funded by National Natural Science Foundation of Beijing (No. 7122187), and Special fund for clinical research of Chinese Medical Association (No. 13040700455).
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leukotriene receptor antagonists BCCA occlusion followed by
2022-09-09
BCCA occlusion, followed by reperfusion injury, significantly increased the brain AT1 and AT2 receptor expression in mice. Reports have demonstrated elevation of AT1 receptor expression in the cerebral leukotriene receptor antagonists during ischemia [34,35]. The gene expression of brain AT2 recept
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br Competing interests br Acknowledgements br Introduction F
2022-09-09
Competing interests Acknowledgements Introduction - Factors Regulating Glucose Tolerance Strictly speaking, the incretin effect refers to the amplification of insulin secretion, which occurs when (R)-PFI 2 hydrochloride is taken in orally as compared to infused intravenously [1]. Normally,
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When testing the novel DA
2022-09-09
When testing the novel DA-CH3 peptide, it was found that it is superior to liraglutide in the MPTP mouse model of PD at a dose of 25 nmol/kg ip once-daily for 7 days. In the Rotarod and grip strength assessment, DA-CH3 was superior to liraglutide in reversing the MPTP–induced motor impairment. Dopam
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Defining the cooperation between molecular pathways within h
2022-09-09
Defining the cooperation between molecular pathways within highly complex biological systems, such as those between immune cell networks and target tissues is certainly a hard task. Recently, there are many investigations in the pathogenesis of renal graft rejection, one of the most evident investig
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In general the FDP gene is involved in isoprenoid biosynthes
2022-09-09
In general the FDP gene is involved in isoprenoid biosynthesis for normal growth and development of plant species while it is specifically involved in rubber biosynthesis (cis-1,4-polyisoprene units) in Hevea plant. When the HbFDP gene was over-expressed under the control of constitutive promoter in
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ADAM has two alternative splicing forms a membrane
2022-09-09
ADAM12 has two alternative splicing forms, a membrane-anchored long form (ADAM12-L) and a secreted short form (ADAM12-S). Both the long and short forms have metalloproteinase, disintegrin, cysteine-rich, and epidermal growth factor-like domains and can shed pro-heparin binding-epidermal growth facto
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CA-074 The conjugated gold is an essential part of rapid
2022-09-08
The conjugated gold is an essential part of rapid test kits. For this PIs-IC strip the gold nanoparticles were conjugated with an optimal concentration of antibody to produce a stable nanoparticle solution (Fig. 3). From TEM images it became obvious that the colloid gold contained particles of diffe
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In the present study we
2022-09-08
In the present study, we investigated the mechanisms underlying the ability of 5-FU to modify histone acetylation. Our results suggested that 5-FU induces global histone de-acetylation in CRC by promoting the degradation of p300 and CBP, two important homologous HATs catalyzing acetylation at multip
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br Discussion As expected RAS
2022-09-08
Discussion As expected, RAS prevalence for treatment-experienced patients who failed therapy with first-wave, first-generation drugs telaprevir/boceprevir was higher compared to non-experienced patients likely due to drug-selective pressure. For non-responders to previous therapy, resistance subs
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In mammals meiotic maturation is the process that couples
2022-09-08
In mammals, meiotic maturation is the process that couples completion of MI with the acquisition of developmental competence to support fertilization (Figure 1). In females there are several hallmark maturation events that are linked to the cell cycle. First, meiosis is not continuous, it is initiat
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br Structural studies of GCAP Recoverin was the first member
2022-09-08
Structural studies of GCAP Recoverin was the first member of this subfamily of Ca2+-binding 891 synthesis to be investigated by structural methods [27], [54], [55], [56], [57], [58]. These proteins have four EF-hands arranged in pairs that give rise to amino- and carboxyl-terminal domains. The c
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